Rivastigmine in Wernicke-Korsakoff’s syndrome: five patients with rivastigmine showed no more improvement than five patients without rivastigmine
18.11.2007
Aims: To evaluate whether rivastigmine, an achetylcholinesteraseinhibitor (AChEl), may be effective in restoring memory in Wernicke-Korsakoff’ssyndrome (WKS). Methods: Five patients treated with rivastigminefor a period of 6 months were compared with five matched controlpatients, who received 6 months’ conventional treatment, butwithout rivastigmine. Memory tests were administered at baselineand after 6 months. Results: Slight improvements were observedin both rivastigmine and control patients, but no significantdifferences in improvements were found between the study groups.Conclusion: Treatment with rivastigmine may not be effectivein restoring memory in WKS patients.
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